- Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Nature neuroscience (2011-05-17)
Ichiro Matsumoto, Makoto Ohmoto, Masataka Narukawa, Yoshihiro Yoshihara, Keiko Abe
PMID21572433
ZUSAMMENFASSUNG
Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells.