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Fluorous synthesis of disubstituted pyrimidines.

Organic letters (2003-03-28)
Wei Zhang
ZUSAMMENFASSUNG

[reaction: see text] The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is substituted with 3-(trifluoromethyl)pyrazole followed by thioether oxidation and tag displacement with amines or thiols. The fluorous chain serves as a phase tag for intermediate and product purification over FluoroFlash SPE cartridges.

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2,4-Dichlor-6-methylpyrimidin, 98%
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