- Synthesis of ether oligomers.
Synthesis of ether oligomers.
Organic letters (2004-01-30)
Olivier Renaudet, Jean-Louis Reymond
PMID14748602
ZUSAMMENFASSUNG
[structure: see text] Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.
MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
Sigma-Aldrich
αα-Chymotrypsin aus Rinderpankreas, Type I-S, essentially salt-free, lyophilized powder