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Merck

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Nature neuroscience (2013-05-28)
Elizabeth M Bradshaw, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
PMID23708142
ZUSAMMENFASSUNG

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
31392
Sigma-Aldrich
Dextran aus Leuconostoc spp., Mr 450,000-650,000
31390
Sigma-Aldrich
Dextran aus Leuconostoc spp., Mr ~70,000
31389
Sigma-Aldrich
Dextran aus Leuconostoc spp., Mr ~40,000
D5376
Sigma-Aldrich
Dextran aus Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
D9260
Sigma-Aldrich
Dextran aus Leuconostoc mesenteroides, average mol wt 9,000-11,000
D8802
Sigma-Aldrich
Dextran -Lösung aus Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)
D8821
Sigma-Aldrich
Dextran aus Leuconostoc mesenteroides, average mol wt 60,000-76,000
D1662
Sigma-Aldrich
Dextran aus Leuconostoc mesenteroides, average mol wt 35,000-45,000
31388
Sigma-Aldrich
Dextran aus Leuconostoc spp., Mr ~6,000
D4876
Sigma-Aldrich
Dextran aus Leuconostoc mesenteroides, average mol wt 150,000
00271
Supelco
Dextran, analytical standard, for GPC, 25,000
09184
Sigma-Aldrich
Dextran aus Leuconostoc spp., Mr ~100,000
00269
Supelco
Dextran, analytical standard, for GPC, 5,000
00268
Supelco
Dextran, analytical standard, for GPC, 1,000
31430
Supelco
Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
31398
Sigma-Aldrich
Dextran aus Leuconostoc mesenteroides, Mr ~200,000