- Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes.
Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes.
Chemical communications (Cambridge, England) (2009-04-11)
Lachlan S Campbell-Verduyn, Leila Mirfeizi, Rudi A Dierckx, Philip H Elsinga, Ben L Feringa
PMID19360172
ZUSAMMENFASSUNG
Monodentate phosphoramidite ligands are used to accelerate the copper(i)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(i) and Cu(ii) salts both function as the copper source in aqueous solution to provide excellent yields.
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