V3639

Valinomycin

Ready Made Solution, ~1 mg/mL in DMSO

• Synonym(e): [(D-Val-L-Lac-Val-D-HyV)(3)](cycl.) (L-Lac: L-Milchsäure, D-HyV: D-α-Hydroxy-isovaleriansäure)
• Empirische Formel (Hill-System): C₅₄H₉₀N₆O₁₈
• CAS-Nummer: 2001-95-8
• Molekulargewicht: 1111.32
• Beilstein: 78657
• MDL-Nummer: MFCD00005114
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 24900743
• NACRES: NA.76

Eigenschaften

• Biologische Quelle: Streptomyces sp.
• Qualitätsniveau: 200
• Assay: ≥90% (HPLC)
• Form: liquid
• Lagerbedingungen: (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
• Konzentration: ~1 mg/mL in DMSO
• Farbe: colorless
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria; parasites; viruses
• Wirkungsweise: cell membrane | interferes
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• SMILES String: CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• InChIKey: FCFNRCROJUBPLU-RPUZOQEISA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: peptide

Anwendung

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

Biochem./physiol. Wirkung

K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): 188.6 °F - closed cup
• Flammpunkt (°C): 87 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter