SML0330

S3I-201

≥97% (HPLC)

• Synonym(e): 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859
• Empirische Formel (Hill-System): C₁₆H₁₅NO₇S
• CAS-Nummer: 501919-59-1
• Molekulargewicht: 365.36
• MDL-Nummer: MFCD09907564
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825335
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: −20°C
• SMILES String: Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
• InChI: 1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
• InChIKey: HWNUSGNZBAISFM-UHFFFAOYSA-N

Beschreibung

Anwendung

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

• to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
• to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
• to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Biochem./physiol. Wirkung

Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable