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Merck

SAB4502117

Sigma-Aldrich

Anti-RXFP3 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

G protein-coupled receptor SALPR, GPCR135, RLN3 receptor 1, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 51 kDa

Speziesreaktivität

rat, human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... RXFP3(51289)

Verwandte Kategorien

Allgemeine Beschreibung

Anti-RXFP3 Antibody detects endogenous levels of total RXFP3 protein.
RXFP3 (relaxin family peptide receptor 3) is also termed as GPCR 135/ SALPR (somatostatin- and angiotensin- like peptide receptor). It is distributed in the central nervous system (CNS), mainly in areas associated with memory, sensory and emotional processing. RXFP3 belongs to the insulin superfamily. This gene is mapped to human chromosome 5p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human RXFP3.

Immunogen Range: 161-210

Biochem./physiol. Wirkung

RXFP3 (relaxin family peptide receptor 3) acts as the cognate receptor for relaxin-3. It controls feeding, motivated behaviors, stress and anxiety. RXFP3 system also modulates alcohol-seeking.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, et al.
Peptides, 84, 44-57 (2016)
Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats.
Calvez J, et al.
Neuropharmacology, 102, 207-215 (2016)
5p13. 3p13. 2 duplication associated with developmental delay, congenital malformations and chromosome instability manifested as low-level aneuploidy.
Iourov IY, et al.
SpringerPlus, 4(1), 616-616 (2015)
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
Alvarez-Jaimes L, et al.
PLoS ONE, 7(2), e30792-e30792 (2012)
Philip J Ryan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20789-20794 (2013-12-04)
Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. Using a rat model of alcohol use and alcohol-seeking, we demonstrated that central administration of peptide antagonists for relaxin family peptide 3 receptor

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