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PZ0016

Sigma-Aldrich

Dofetilid

≥98% (HPLC), powder, hERG channel blocker

Synonym(e):

N-[4-[2-[Methyl-[2-[4-[(methylsulfonyl)-amino]-phenoxy]-ethyl]-amino]-ethyl]-phenyl]-methansulfonamid

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About This Item

Empirische Formel (Hill-System):
C19H27N3O5S2
CAS-Nummer:
115256-11-6
Molekulargewicht:
441.56
MDL-Nummer:
MFCD00869707
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329823685
NACRES:
NA.77

product name

Dofetilid, ≥98% (HPLC)

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

DMSO: >20 mg/mL

Lagertemp.

room temp

SMILES String

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2

InChI

1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

InChIKey

IXTMWRCNAAVVAI-UHFFFAOYSA-N

Angaben zum Gen

human ... KCNH2(3757)

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Biochem./physiol. Wirkung

Dofetilide is a Class III antiarrhythmic and hERG channel blocker. Dofetilide selectively blocks the rapid component of the delayed rectifier outward potassium current (IKr).

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Health hazardEnvironment
GHS08,GHS09

Signalwort

Danger

Gefahreneinstufungen

Aquatic Chronic 2 - Repr. 1B - STOT RE 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Hanne Elming et al.
Expert opinion on pharmacotherapy, 4(6), 973-985 (2003-06-05)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Mortality, and especially morbidity caused by AF, are major and growing health problems in the western world. AF is strongly associated with arterial hypertension, congestive heart failure, valvular heart disease, ischaemic
S Durdagi et al.
Current medicinal chemistry, 18(17), 2601-2611 (2011-05-17)
The binding of various molecules to integral membrane proteins with optimal affinity and specificity is central to normal function of cell. While membrane proteins represent about one third of the whole cell proteome, they are a majority of common drug
Thom R G Stams et al.
European journal of pharmacology, 672(1-3), 126-134 (2011-10-18)
The novel antiarrhythmic drug K201 (4-[3-{1-(4-benzyl)piperidinyl}propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine monohydrochloride) is currently in development for treatment of atrial fibrillation. K201 not only controls intracellular calcium release by the ryanodine receptors, but also possesses a ventricular action that might predispose to torsade de pointes
Daniel M Johnson et al.
Circulation. Arrhythmia and electrophysiology, 5(1), 201-209 (2011-11-15)
AZD1305 is an investigational antiarrhythmic agent for management of atrial fibrillation. It blocks various cardiac ion currents at different potencies and has atrial-predominant electrophysiological effects. We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic
Cardiovascular drugs. Dofetilide.
J P Mounsey et al.
Circulation, 102(21), 2665-2670 (2000-11-22)
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