Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

B4813

Sigma-Aldrich

BGP-15

≥98% (HPLC)

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C14H22N4O2· 2HCl
CAS-Nummer:
66611-37-8
Molekulargewicht:
351.27
MDL-Nummer:
MFCD21603901
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329773244
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Löslichkeit

deionized water: 28 mg/mL

Lagertemp.

−20°C

SMILES String

Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c2cccnc2

InChI

1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H

InChIKey

ISGGVCWFTPTHIX-UHFFFAOYSA-N

Allgemeine Beschreibung

BGP-15 is a hydroxylamine derivative, which has cytoprotective and neuroprotective properties. It reduces phospho- c-Jun N-terminal kinase (pJNK) and p38 stress signalling. BGP-15 also stimulates non-specific serine/threonine protein kinase (AKT) and insulin-like growth factor 1 receptor (IGFR1) protective signalling. BGP-15 functions as an insulin sensitizer in an olanzapine-induced metabolic disorder. It protects cells against cell death and enhances the expression of heat shock protein (HSP). BGP-15 might be used to treat heart failure (HF) and atrial fibrillation (AF).

Anwendung

BGP-15 has been used to study its influence on proteasomal degradation of missense dystrophins.

Biochem./physiol. Wirkung

BGP-15 is PARP inhibitor, HSP72 activator.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

BGP-15 protects against oxidative stress-or lipopolysaccharide-induced mitochondrial destabilization and reduces mitochondrial production of reactive oxygen species
Sumegi K, et al.
PLoS ONE, 12(1), e0169372-e0169372 (2017)
Disease-proportional proteasomal degradation of missense dystrophins
Talsness DM, et al.
Proceedings of the National Academy of Sciences of the USA, 112(40), 12414-12419 (2015)
BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia
Ohlen SB, et al.
Proceedings of the National Academy of Sciences of the USA, 114(19), 5035-5040 (2017)
Urszula Brykczynska et al.
Cell reports, 30(5), 1627-1643 (2020-02-06)
The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we
Geeta Sapra et al.
Nature communications, 5, 5705-5705 (2014-12-10)
Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high mortality. Treatment of HF with AF represents a major unmet need. Here we show that a small molecule, BGP-15, improves cardiac function

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.