26745
Cholesterinesterase aus Schweinepankreas
lyophilized, powder, white, ~35 U/mg
Synonym(e):
Cholesterin-Esterase aus Schweinepankreas
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About This Item
Empfohlene Produkte
Biologische Quelle
Porcine pancreas
Form
powder
Qualität
lyophilized
Spezifische Aktivität
~35 U/mg
Mol-Gew.
Mr ~440000
Farbe
white
Lagertemp.
−20°C
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Allgemeine Beschreibung
Research area: Cell signaling
Pancreatic cholesterol esterase (CEase), also known as bile salt stimulated lipase, is a serine hydrolase belonging to the α/β hydrolase family of enzymes. They are released from the exocrine pancreas. Serine 194, histidine 435 and aspartate 320 represent the catalytic triad of the enzyme.
Pancreatic cholesterol esterase (CEase), also known as bile salt stimulated lipase, is a serine hydrolase belonging to the α/β hydrolase family of enzymes. They are released from the exocrine pancreas. Serine 194, histidine 435 and aspartate 320 represent the catalytic triad of the enzyme.
Anwendung
Cholesterol Esterase from porcine pancreas has been used:
- in an in vitro simulated digestion model to improve the hydrolysis of carotenoid esters in the intestinal phase
- to analyze the bioavailability of phytosterol and cholesterol in the aqueous micellar phase of an in vitro simulated digestion model
- as a standard in enzyme activity assay
Biochem./physiol. Wirkung
Cholesterol esterase (CEase), an enzyme having broad substrate specificity plays a key role in regulating the bile salt mediated hydrolysis of dietary cholesteryl esters. It also participates in the hydrolysis of triglycerides and phospholipids which are essential for normal cholesterol absorption. Cholesterol esterase hydrolysis helps in the determination of total cholesterol levels in the serum and plasma. Additionally, cholesterol esterase (CEase) along with phospholipase A2 is involved in the hydrolysis of lecithin to lysolecithin, forming intestinal micelles that deliver free cholesterol to enterocytes. Loss of enzyme function results in reduced intestinal absorption of dietary cholesteryl esters and prevents the formation of intestinal micelles, thereby failing to deliver cholesterol efficiently. Circulating cholesterol esterases, accumulated in atherosclerotic lesions are involved in triggering the proliferation of smooth muscle cells. Lastly, they are also selectively involved in the hydrolysis/condensation of carboxylic ester bonds.
Einheitendefinition
1 U entspricht der Enzymmenge, die 1 μmol Cholesterin pro Minute bei pH 7.0 und 37°C freisetzt (Cholesterin-acetat als Substrat)
Sonstige Hinweise
Kann Verkaufsbeschränkungen unterliegen.
Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizing CEase inhibitors. In the present study, we prepared forty-five isocoumarin
R.J. Kazlauskas
Journal of the American Chemical Society, 111, 4953-4953 (1989)
J. Siedel et al.
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KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness. Thus, inhibitors of KIAA1363 represent a novel targeted therapy approach towards cancer. AX11890 ((1-bromo-2-naphthyl) N,N-dimethylcarbamate) was identified as a KIAA1363 inhibitor with
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