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03394

Sigma-Aldrich

Poly(ethylenglykol)

tested according to Ph. Eur., 6,000

Synonym(e):

Macrogolum 6′000, PEG

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About This Item

Lineare Formel:
H(OCH2CH2)nOH
CAS-Nummer:
25322-68-3
MDL-Nummer:
MFCD00081839
UNSPSC-Code:
12352104
PubChem Substanz-ID:
24845475
NACRES:
NA.21

Agentur

tested according to Ph. Eur.

Qualitätsniveau

200

Form

solid

Mol-Gew.

5000-7000

Löslichkeit

aliphatic hydrocarbons: slightly soluble
organic solvents: soluble

Anwendung(en)

pharmaceutical (small molecule)

SMILES String

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChIKey

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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Anwendung

Poly(ethylene glycol) was used as hydrophilic carriers for characterizing the sirolimus solid dispersion nanoparticles.

Biochem./physiol. Wirkung

Polyethylene glycol (PEG) is a condensation polymer of ethylene oxide and water. It enhances the refolding of extracted proteins. This enables characterization of crystallized proteins.

Angaben zur Herstellung

Poly(ethylene glycol) dissolves in many organic solvents and is readily soluble in aromatic hydrocarbons. It also slightly dissolves in aliphatic hydrocarbons.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
BCCJ9479
BCCJ4105
BCCH7100
BCCH2539
BCCG5481

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Polyethylenglycol 6000, Molecular Biology Grade

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Poly(ethylenglykol) tested according to Ph. Eur., 4,000

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Poly(ethylenglykol)

Poly(ethylenglykol) average Mv ~8,000, powder (crystalline)

Sigma-Aldrich

202452

Poly(ethylenglykol)

Poly(ethylenglykol) for molecular biology, average mol wt 8,000

Sigma-Aldrich

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Poly(ethylenglykol)

Kolliphor P 188

Sigma-Aldrich

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J L Cleland et al.
Bio/technology (Nature Publishing Company), 10(9), 1013-1019 (1992-09-01)
Previous studies on the refolding of recombinant bovine carbonic anhydrase B (CAB) indicated that polyethylene glycol (PEG) significantly enhanced the recovery of active protein by reducing aggregation. To further test the ability of PEG to enhance refolding, three recombinant human
J L Cleland et al.
The Journal of biological chemistry, 267(19), 13327-13334 (1992-07-05)
Polyethylene glycol (PEG) inhibited aggregation during refolding of bovine carbonic anhydrase B (CAB) through the formation of a nonassociating PEG-intermediate complex. Stoichiometric concentrations of PEG were required for complete recovery of active protein during refolding at aggregating conditions. For example
Min-Soo Kim et al.
International journal of nanomedicine, 6, 2997-3009 (2011-12-14)
The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process. First, excipients for enhancing the stability and solubility of
Idalis Villanueva et al.
Acta biomaterialia, 5(8), 2832-2846 (2009-06-11)
The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene
Mark A Rice et al.
Acta biomaterialia, 5(1), 152-161 (2008-09-17)
Ultrasound has potential as a non-destructive analytical technique to provide real-time online assessments of matrix evolution in cell-hydrogel constructs used in tissue engineering. In these studies, chondrocytes were encapsulated in poly(ethylene glycol) hydrogels, and gel degradation was manipulated to provide
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