MABE959

Anti-MBNL2 Antibody, clone MB2a(3B4)

clone MB2a(3B4), 1 mg/mL, from mouse

• Synonym(e): Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, Muscleblind-like protein-like 39
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: MB2a(3B4), monoclonal
• Speziesreaktivität: mouse
• Speziesreaktivität (Voraussage durch Homologie): human (based on 100% sequence homology)
• Konzentration: 1 mg/mL
• Methode(n): western blot: suitable
• Isotyp: IgG2bκ
• NCBI-Hinterlegungsnummer: NP_659002
• UniProt-Hinterlegungsnummer: Q5VZF2
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MBNL2(10150)

Beschreibung

Allgemeine Beschreibung

MBNL2, also known as Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, or Muscleblind-like protein-like 39, and encoded by the gene MBNL2/MBLL/MBLL39/MLP1, is a protein that mediates pre-mRNA alternative splicing regulation. MBNL2 acts either as an activator or repressor of splicing on specific pre-mRNA targets. For instance MBNL2 inhibits cardiac troponin-T pre-mRNA exon inclusion but induces insulin receptor pre-mRNA exon inclusion in muscle. MBNL2 may also regulate ITGA3 expression by transporting it from the nucleus to cytoplasm at adhesion plaques. MBNL2 appears to play a key role in the muscle disease named myotonic dystrophy pathophysiology. MBNL2 is expressed in the nucleus of cells in multiple tissues but can be found in the cytoplasm in certain situations. In particular it is found in the cytoplasm in adhesion plaques.

Immunogen

Recombinant protein corresponding to human MBNL2.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
Nuclear Receptors

This Anti-MBNL2 Antibody, clone MB2a(3B4) is validated for use in Western Blotting for the detection of MBNL2.

Qualität

Evaluated by Western Blotting in C2C12 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MBNL2 in 10 µg of C2C12 cell lysate.

Zielbeschreibung

~40 kDa observed

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable