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Key Documents

MABE450

Sigma-Aldrich

Anti-TAF15, clone 8TA-2B10 Antibody

ascites fluid, clone 8TA-2B10, from mouse

Synonym(e):

TATA-binding protein-associated factor 2N, 68 kDa TATA-binding protein-associated factor, TAF(II)68, TAFII68, RNA-binding protein 56

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

ascites fluid

Antikörper-Produkttyp

primary antibodies

Klon

8TA-2B10, monoclonal

Speziesreaktivität

rat, mouse, human

Methode(n)

immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1κ

NCBI-Hinterlegungsnummer

NP_003478

UniProt-Hinterlegungsnummer

Q92804

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... TAF15(8148)

Allgemeine Beschreibung

TAF15, also known as TATA-binding protein-associated factor 2N, or 68 kDa TATA-binding protein-associated factor, or TAF(II)68, TAFII68, or RNA-binding protein 56, and encoded by the gene TAF15/RBP56/TAF2N, is a RNA and ssDNA binding protein important in transcription initiation. TAF15 aligns with the RNA polymerase II (Pol II) multiprotein complex that together with other proteins like TBP initiates transcription. TAF15 is ubiquitously expressed, and TAF15 shuttles from the nucleus to the cytoplasm upon activation; methylation of TAF15 appears to guide nuclear localization and transcriptional activity. Translocations involving the TAF15 gene may play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene are associated with amyotrophic lateral sclerosis (ALS) diseases.

Anwendung

Anti-TAF15 antibody, clone 8TA-2B10 is an antibody against TAF15 for use in western blotting & IP.

Qualität

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected TAF15 in 10 µg of A431 cell lysate.

Zielbeschreibung

~68 kDa observed

Physikalische Form

Mouse monoclonal IgG1κ ascites without preservatives.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

M Ballarino et al.
Oncogene, 32(39), 4646-4655 (2012-11-07)
TAF15 (formerly TAFII68) is a member of the FET (FUS, EWS, TAF15) family of RNA- and DNA-binding proteins whose genes are frequently translocated in sarcomas. By performing global gene expression profiling, we found that TAF15 knockdown affects the expression of
Yan Wang et al.
Oncotarget, 8(67), 111866-111881 (2018-01-18)
S-adenosyl methionine (SAM) is a ubiquitous methyl donor that was reported to have chemo- protective activity against liver cancer, however the molecular footprint of SAM is unknown. We show here that SAM selectively inhibits growth, transformation and invasiveness of hepatocellular

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