MAB4617

Anti-Survivin Antibody, clone 8E2

clone 8E2, Chemicon^®, from mouse

• Synonym(e): TIAP
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 8E2, monoclonal
• Speziesreaktivität: human
• Hersteller/Markenname: Chemicon^®
• Methode(n): ELISA: suitable; immunofluorescence: suitable
• Isotyp: IgG1
• Eignung: not suitable for Western blot
• NCBI-Hinterlegungsnummer: NM_001012270.1; NM_001012271.1; NM_001168.2
• UniProt-Hinterlegungsnummer: O15392
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BIRC5(332)

Beschreibung

Allgemeine Beschreibung

Survivin, an inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin′s anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

Spezifität

MAB4617 detects human survivin (16.5 kDa).

Immunogen

Full length recombinant human survivin

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
BCL2 & Hemmung

Detect Survivin using this Anti-Survivin Antibody, clone 8E2 validated for use in ELISA & IF.

Immunofluorescence

ELISA (for detection only)

Does not work for Western Blot

Does not work for Immunohistochemistry

Optimal working dilutions must be determined by end user.

Verlinkung

Replaces: MAB3509

Physikalische Form

Format: Purified

Purified immunoglobulin, by Protein G. Liquid in 10 mM PBS, pH 7,4 containing 0.2% BSA and 0.09% sodium azide.

Lagerung und Haltbarkeit

Maintain at 2-8°C for up to 12 months.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable