AB2277

Anti-FOXP1 Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): fork head-related protein like B, forkhead box P1, glutamine-rich factor 1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: rhesus macaque, rat, mouse, human
• Speziesreaktivität (Voraussage durch Homologie): bovine (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology)
• Methode(n): immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_116071
• UniProt-Hinterlegungsnummer: Q9H334
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... FOXP1(27086)

Beschreibung

Allgemeine Beschreibung

Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development.

Spezifität

This antibody recognizes the C-terminus of FOXP1.

Immunogen

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human FOXP1.

Anwendung

Research Category
Neurowissenschaft

Epigenetik & nukleäre Funktionen

Research Sub Category
Transkriptionsfaktoren

Transkriptionsfaktoren

Anti-FOXP1 Antibody detects level of FOXP1 & has been published & validated for use in WB, IC, IH.

Immunohistochemistry Analysis: A 1:300 dilution of AB2277 from a previous lot detected FOXP1 in inflammatory skin disorder and normal human kidney-glomerulus tissue.

Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected FOXP1 in NIH/3T3, RAW264.7, and HeLa cells.

Qualität

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected multiple isoforms of FOXP1 in 10 µg of Jurkat cell lysate.

Zielbeschreibung

FOXP1 has 4 isoforms observed at 75/73, 64 and 54 kDa

Physikalische Form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Jurkat cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable