440205-M

LY 83583

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

• Synonym(e): LY 83583, 6-Anilino-5,8-quinolinequinone
• Empirische Formel (Hill-System): C₁₅H₁₀N₂O₂
• CAS-Nummer: 91300-60-6
• Molekulargewicht: 250.25
• MDL-Nummer: MFCD00210756
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: red-purple
• Löslichkeit: ethanol: 3 mg/mL; acetone: soluble
• Lagertemp.: 2-8°C
• InChI: 1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
• InChIKey: GXIJYWUWLNHKNW-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.

Biochem./physiol. Wirkung

Primary Target
soluble guanylate cyclase

Target IC₅₀: 2 µM against soluble guanylate cyclase

Warnhinweis

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Rekonstituierung

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

Sonstige Hinweise

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable