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Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)

PEG average Mn 2,000, PDLLA average Mn 2,000

Synonym(e):

PEG-PDLLA

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About This Item

UNSPSC-Code:
12162002
NACRES:
NA.23

Beschreibung

n=45, m=28 (typical)
typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)

Form

pellets

Mol-Gew.

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

Zeitrahmen für den Abbau

2-4 weeks

Übergangstemp.

Tg 11 °C (PEG block)
Tm 244-248 °C
Tg 88 °C (PDLLA block)

PDI

≤1.4

Lagertemp.

2-8°C

Allgemeine Beschreibung

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.

Anwendung

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
water-solubilization of drugs

Leistungsmerkmale und Vorteile

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Methoxy poly(ethylene glycol)-b-poly(D,L-lactide) 2k-5k

Sigma-Aldrich

900657

Methoxy poly(ethylene glycol)-b-poly(D,L-lactide)

Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
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Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing

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