TERT
telomerase reverse transcriptase
Synonyme:
CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
Spezies:
Human TERT (7015), Mouse Tert (21752), Rat Tert (301965), Thale Cress TERT (831548), domestic cat TERT (100144612), dog TERT (403412), chicken TERT (420972), Zebrafish tert (796551), naked mole-rat Tert (101706965), domestic guinea pig Tert (100732437) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(7015) Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
- Mouse(21752) telomerase reverse transcriptase
- Rat(301965) telomerase reverse transcriptase
- Thale Cress(831548) telomerase reverse transcriptase
- domestic cat(100144612) telomerase reverse transcriptase
- dog(403412) telomerase reverse transcriptase
- chicken(420972) telomerase reverse transcriptase
- Zebrafish(796551) telomerase reverse transcriptase
- naked mole-rat(101706965) telomerase reverse transcriptase
- domestic guinea pig(100732437) telomerase reverse transcriptase
- cow(518884) telomerase reverse transcriptase
- sheep(100126866) telomerase reverse transcriptase
- sheep(101112422) telomerase reverse transcriptase
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-TERT-Antikörper, from rabbit, purified by affinity chromatography,
Speziesreaktivität
human, mouse, rat, rhesus macaque
Anwendung
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TERT (human) Antikörper, Klon 2C4, clone 2C4, from mouse,
Speziesreaktivität
human
Anwendung
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-TERT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence
Anti-Telomerase antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
ELISA
western blot
western blot
Anti-Telomerase antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence
immunofluorescence
Small Molecule - Inhibitor
Produktnummer
Beschreibung
Spezies
Neomycin -Lösung, with 10 mg/mL neomycin in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture,
Spezies
human
esiRNA
Produktnummer
Beschreibung
Spezies