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KMT2A

lysine (K)-specific methyltransferase 2A

Synonyme:
ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS
Spezies:
Human KMT2A (4297), Mouse Kmt2a (214162), Rat Kmt2a (315606), domestic guinea pig Kmt2a (100727230), naked mole-rat Kmt2a (101716671), Zebrafish kmt2a (557048), cow KMT2A (508330)
UniProtKB-ID:
Q03164, E9PQG7, Q13743, Q13744, Q14845, Q16364, Q59FF2, Q6UBD1
Gen-ID:
  • Human(4297) Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
  • Mouse(214162) lysine (K)-specific methyltransferase 2A
  • Rat(315606) lysine (K)-specific methyltransferase 2A
  • domestic guinea pig(100727230) lysine (K)-specific methyltransferase 2A
  • naked mole-rat(101716671) lysine (K)-specific methyltransferase 2A
  • Zebrafish(557048) lysine (K)-specific methyltransferase 2A
  • cow(508330) lysine (K)-specific methyltransferase 2A

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
05-765
Anti-MLL/HRX-Antikörper, CT, Klon 9-12, clone 9-12, Upstate®, from mouse,
Speziesreaktivität
human, mouse
Anwendung
ChIP
immunofluorescence
immunoprecipitation (IP)
western blot
ABE344
Anti-Acetyl MLL1 (KMT2A) (Lys 1130/1133), from rabbit,
Speziesreaktivität
human, mouse
Anwendung
dot blot
inhibition assay
western blot
05-764
Anti-MLL/HRX-Antikörper, NT., Klon N4.4, clone N4.4, Upstate®, from mouse,
Speziesreaktivität
human, mouse
Anwendung
immunoprecipitation (IP)
western blot
HPA044910
Anti-KMT2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence

esiRNA

Produktnummer
Beschreibung
Spezies
EHU098161
MISSION® esiRNA, targeting human KMT2A,
Spezies
human