HSPG2
heparan sulfate proteoglycan 2
Synonyme:
HSPG, PLC, PRCAN, SJA, SJS, SJS1
Spezies:
Human HSPG2 (3339), Mouse Hspg2 (15530), Rat Hspg2 (117511), Zebrafish hspg2 (565429), cow HSPG2 (444872), Horse HSPG2 (100071701), domestic cat HSPG2 (101094520), dog HSPG2 (403440), chicken HSPG2 (429806), sheep HSPG2 (101122677) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(3339) Summary: This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010]
- Mouse(15530) perlecan (heparan sulfate proteoglycan 2)
- Rat(117511) heparan sulfate proteoglycan 2
- Zebrafish(565429) heparan sulfate proteoglycan 2
- cow(444872) heparan sulfate proteoglycan 2
- Horse(100071701) heparan sulfate proteoglycan 2
- domestic cat(101094520) heparan sulfate proteoglycan 2
- dog(403440) heparan sulfate proteoglycan 2
- chicken(429806) heparan sulfate proteoglycan 2
- sheep(101122677) heparan sulfate proteoglycan 2
- Domestic Rabbit(100340334) heparan sulfate proteoglycan 2
- sheep(100294588) heparan sulfate proteoglycan 2
- domestic guinea pig(100718406) heparan sulfate proteoglycan 2
- naked mole-rat(101700294) heparan sulfate proteoglycan 2
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ELISA
Produktnummer
Beschreibung
Spezies
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Heparansulfat-Proteoglykan (Perlecan) Antikörper, Klon A7L6, clone A7L6, from rat,
Speziesreaktivität
human
Anwendung
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Heparin/Heparansulfat-Antikörper, Klon T320.11, clone T320.11, Chemicon®, from mouse,
Speziesreaktivität
mammals
Anwendung
ELISA
radioimmunoassay
western blot
radioimmunoassay
western blot
Anti-Heparansulfat-Proteoglykan(Perlecan)-Antikörper, Klon 5D7-2E4, clone 5D7-2E4, from mouse,
Speziesreaktivität
human
Anwendung
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-HSPG2 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse
Anwendung
immunohistochemistry
western blot
western blot
Anti-Estrogen Receptor Antibody, clone B10, ascites fluid, clone B10, Chemicon®,
Speziesreaktivität
human, rat
Anwendung
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot