DIO2
deiodinase, iodothyronine, type II
Synonyme:
5DII, D2, DIOII, SelY, TXDI2
Spezies:
Human DIO2 (1734), Mouse Dio2 (13371), Rat Dio2 (65162), domestic guinea pig Dio2 (100721073), naked mole-rat Dio2 (101697296), Goat DIO2 (100861220), Domestic Rabbit DIO2 (100354221), sheep DIO2 (100310793), Zebrafish dio2 (352937), chicken DIO2 (373903) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(1734) Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(13371) deiodinase, iodothyronine, type II
- Rat(65162) deiodinase, iodothyronine, type II
- domestic guinea pig(100721073) deiodinase, iodothyronine, type II
- naked mole-rat(101697296) deiodinase, iodothyronine, type II
- Goat(100861220) deiodinase, iodothyronine, type II
- Domestic Rabbit(100354221) deiodinase, iodothyronine, type II
- sheep(100310793) deiodinase, iodothyronine, type II
- Zebrafish(352937) deiodinase, iodothyronine, type II
- chicken(373903) deiodinase, iodothyronine, type II
- domestic cat(101088170) deiodinase, iodothyronine, type II
- cow(494548) deiodinase, iodothyronine, type II
- Horse(100052547) deiodinase, iodothyronine, type II
- dog(490813) deiodinase, iodothyronine, type II
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-DIO2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence
esiRNA
Produktnummer
Beschreibung
Spezies