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CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Synonyme:
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Spezies:
Human CDKN1B (1027), Mouse Cdkn1b (12576), Rat Cdkn1b (83571), chicken CDKN1B (374106), dog CDKN1B (403429), cow CDKN1B (512613), domestic cat CDKN1B (493958), chicken CDKN1B (769872), naked mole-rat Cdkn1b (101698721), domestic guinea pig Cdkn1b (100729359) ...Mehr
UniProtKB-ID:
P46527, Q16307, Q5U0H2, Q9BUS6
Gen-ID:
  • Human(1027) Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
  • Mouse(12576) cyclin-dependent kinase inhibitor 1B
  • Rat(83571) cyclin-dependent kinase inhibitor 1B
  • chicken(374106) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • dog(403429) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cow(512613) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic cat(493958) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • chicken(769872) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • naked mole-rat(101698721) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic guinea pig(100729359) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • sheep(100127219) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • Domestic Rabbit(100009037) cyclin-dependent kinase inhibitor 1B (p27, Kip1)

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
SAB4504200
Anti-phospho-p27 Kip1 (pThr198) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
western blot
WH0001027M1
Monoclonal Anti-CDKN1B antibody produced in mouse, clone 4B4-E6, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
06-996
Anti-phospho-Kip1 (Thr187) Antibody, Upstate®, from rabbit,
Speziesreaktivität
human, mouse, rat
Anwendung
western blot
06-445
Anti-Kip1 (p27) Antibody, Upstate®, from rabbit,
Speziesreaktivität
human, rabbit, rat
Anwendung
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4500068
Anti-p27 KIP1 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
R7772
Roscovitine, ≥98% (TLC),
Spezies
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Spezies
human, rat

Proteins

Produktnummer
Beschreibung
Spezies
SRP5109
p27KIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Spezies
human
23-024-M
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
EMU028461
MISSION® esiRNA, targeting mouse Cdkn1b,
Spezies
mouse
EHU025821
MISSION® esiRNA, targeting human CDKN1B,
Spezies
human