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APH1B

APH1B gamma secretase subunit

Synonyme:
APH-1B, PRO1328, PSFL, TAAV688
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(83464) Summary: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
  • Mouse(208117) anterior pharynx defective 1b homolog (C. elegans)
  • Rat(300802) anterior pharynx defective 1 homolog B (C. elegans)
  • sheep(101111553) anterior pharynx defective 1 homolog B (C. elegans)
  • naked mole-rat(101712646) APH1B gamma secretase subunit
  • domestic guinea pig(100718283) APH1B gamma secretase subunit
  • Zebrafish(386808) anterior pharynx defective 1B
  • dog(487589) anterior pharynx defective 1 homolog B (C. elegans)
  • Horse(100067205) anterior pharynx defective 1 homolog B (C. elegans)
  • cow(530913) anterior pharynx defective 1 homolog B (C. elegans)

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-APH1B antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Begacestat, ≥98% (HPLC),
Spezies
human
DAPT, ≥98% (HPLC), solid,
Spezies
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Spezies
mouse, human, rat

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting mouse Aph1b,
Spezies
mouse
MISSION® esiRNA, targeting human APH1B,
Spezies
human