AccueilApplicationsDomaines de recherche et thérapeutiquesPharmacologie et recherche pharmaceutique (drug discovery)
Pharmacologie et recherche pharmaceutique (drug discovery)
Articles techniques apparentés
- Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.
- Target identification, validation and characterization for early stages of drug discovery. Identifying drug target via genetic association, expression profiling.
- Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication.
- 3D cell culture overview. Learn about 2D vs 3D cell culture, advantages of 3D cell culture, and techniques available to develop 3D cell models
- We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
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Protocoles apparentés
- Properties of lipid formulations can vary depending on the composition (cationic, anionic, neutral lipid species), however, the same preparation method can be used for all lipid vesicles regardless of composition. The general elements of the procedure involve preparation of the lipid for hydration, hydration with agitation, and sizing to a homogeneous distribution of vesicles.
- General Lipid/BSA solubility protocol for cell delivery. Organic solvent suspended method for the preparation of lipid stock solutions.
- HDM-PAMPA with the MultiScreen Permeability Filter Plate
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