Authenticated Lung Cancer Cell Lines for Cancer Research
Lung cancer is the leading cause of cancer-related death. Patients are frequently diagnosed at an advanced stage due to a relative lack of clinical symptoms. Lung cancer accounts for 13.2% of all new cancers and 25.9% of all cancer deaths each year. The overall five-year survival rate of lung cancer is lowest (18.1%) when compared to most other cancers1, but prognosis varies dramatically with pathological classification, disease stage, and patient demographics such as gender and age at diagnosis.
Types of lung cancer
The pathological classification of lung cancer is evolving. It is currently histopathologically classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC)—which includes squamous cell carcinoma and adenocarcinoma. NSCLC, sometimes referred to as large cell lung carcinoma, accounts for the majority (85%) of lung cancer diagnoses.
Risk factors
The incidence of lung cancer is declining in developed countries, due in part to smoking education and regulation. Incidence rates are rising, however, in less developed countries. That 80% of men and 50% of women with lung cancer are smokers demonstrates smoking as the lifestyle risk factor. Environmental risk factors include passive smoke exposure, air pollution, and other sources of particulate inhalation.
Mutations
Genetic predisposition amplifies the risk of lung cancer, and lung adenocarcinoma is more associated than other histotypes with genetic factors. The most frequently reported somatic mutations in lung cancer are in the genes for TP53, LRP1B, KRAS, KEAP1, KMT2C, FAT4, CDKN2A, EGFR, and FAT2.
Select cell lines from the table below based on mutation, and click on genes to find relevant products (antibodies, shRNA, siRNA, primers, CRISPR plasmids) for your research application.
Small molecules/monoclonal antibodies
Small molecule compounds and antibodies can be used to target specific cancer cells and block tumor growth and progression. The most common drugs used to target lung cancer include:
Applications
Cancer cell lines have been at the heart of cancer research, and provide an accessible, cost-effective model for cellular behavior and response. Based on the characteristics of the cell line and experimental need, cell lines may be used in one or more applications. Some examples of application-specific use for cell lines associated with lung cancer are included below.
ECACC Lung Cancer Cell Lines |
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References
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