Cyclodextrin Solubility Table
Table includes the solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl β-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.
Compound | Solubility in Water (mg/mL) | Solubility in 45% w/v 2-Hydroxylpropyl β-cyclodextrin (mg/mL) | Solubility Enhancement |
---|---|---|---|
Acetazolamide | 0.7 | 17 | 24 |
6,7-ADTN HBr | 0.56 | 5.6 | 10 |
R(–)-N-Allylnorapomorphine HBr | 0.3 | 1.6 | 5.5 |
p-Aminoclonidine HCl | 0.43 | 1.4 | 3.3 |
(±)-p-Aminoglutethimide | 0.16 | 1.2 | 7.5 |
R(+)-Atenolol | <0.01 | 6 | >600 |
S(–)Atenolol | <0.01 | 6 | >600 |
Butaclamol | 0.25 | 5.4 | 21 |
Chloramphenicol | 2.5 | 53 | 21 |
4'-Chlordiazepam | <0.01 | 1.5 | >150 |
Chlorthalidone | 0.12 | 8 | 67 |
CNQX | <0.10 | 0.8 | 7.5 |
Codeine sulfate | 3.3 | 4.3 | 1.3 |
CV-1808 | <0.07 | 3.6 | 54 |
8-Cylclopentyl-1,3-p-sulfophenylxanthine | <0.20 | 0.8 | 4 |
Dexamethasone | <0.01 | 24 | 3000 |
Diazepam | 0.05 | 5 | 100 |
Digoxin | 0.07 | 52 | 743 |
7,9-Dimethyluric acid | <0.01 | 0.4 | >36 |
7,9-Dimethylxanthine | 0.75 | 1.4 | 1.9 |
3,5-Dinitrocatechol | 0.17 | 2.8 | 16.5 |
1,3-Dipropyl-8-p-sulfophenylxanthine | 0.43 | 6.8 | 16 |
DNQX | <0.10 | 1.9 | 7.6 |
(S)-ENBA | <0.09 | 2.8 | >30 |
Estradiol | <0.01 | 21 | 5250 |
FG-7142 | 0.07 | 1.8 | 27 |
Furosemide | 0.07 | 1 | 14 |
L-Glutamic acid HCl | 3.3 | 8.7 | 2.6 |
L-Glutamic acid diethyl ester HCl | 3.3 | 8.7 | 2.6 |
Glutethimide | 0.26 | 6 | 23 |
Haloperidol | <0.20 | 0.4 | 2.3 |
Hexahydro-sila-difenidol HCl | <0.01 | 5.7 | >570 |
Hexahydro-sila-difenidol HCl, p-fluoro analog | <1.50 | >14 | >9.3 |
Hydrocortisone | 0.28 | 24 | 86 |
6-Hydroxydopamine HBr | 3.3 | 5.3 | 1.6 |
3-Hydroxymethyl-ß-carboline | <0.20 | 0.4 | 2.5 |
Indomethacin | 0.02 | 3 | 150 |
Iodotubercidin | <0.16 | 0.9 | >5.8 |
Isobutylmethylxanthine | 0.3 | 0.2 | 10 |
(–)-MDO-NPA HCl | 1.5 | 4.1 | 2.7 |
Methotrexate | 0.04 | 8 | 178 |
2-Methylthio ATP | 1.5 | 3.3 | 2.2 |
Naltrindole HCl | 0.1 | 2.2 | 22 |
Quabain | 12.2 | 61 | 5 |
Papaverine HCl | <0.25 | 4 | >16 |
2-Phenylaminoadenosine | <0.01 | 3.6 | >360 |
Phenytoin | 0.02 | 7 | 350 |
R(–)-PIA | 0.3 | 1.6 | 5.3 |
S(+)-PIA | 1.2 | 5 | 4.2 |
Pirenperone | <0.19 | 0.8 | >4.1 |
Prochlorperazine | 0.25 | 2.3 | 9.2 |
Progesterone | 0.02 | 39 | 2600 |
DL(±)-Propranolol | 3.3 | 8 | 2.4 |
(–)-Quisqualic acid | 0.52 | 1.3 | 2.5 |
Ranitidine HCl | 1.8 | 7 | 3.9 |
Ro 15-4513 | <0.01 | 0.8 | >80 |
Ro 20-1724, PDE inhibitor | <0.01 | 5 | >500 |
Ro 41-0960, COMT inhibitor | <0.70 | 1 | >1.4 |
Ryanodine | <0.14 | 1.3 | >9.3 |
SKF-83566 HCl | <0.01 | 14 | >1400 |
Spiperone HCl | 0.2 | 2 | 10 |
Sulpride | <0.21 | 8 | >38 |
Testosterone | 0.03 | 30 | 1154 |
Tetrahydrocannabinol | <0.01 | 2 | 455 |
Veratridine | <1 | >2 | >2 |
Vitamin A | 0.01 | 5 | 500 |
Vitamin D | <0.23 | 8 | >35 |
Materials
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