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Progress in a selective method for the determination of the acetaldehyde-derived DNA adducts by using HILIC-ESI-MS/MS.

Talanta (2017-11-08)
Hiroya Murakami, Ruri Horiba, Tomoko Iwata, Yuta Miki, Bunji Uno, Tadao Sakai, Kazuhiro Kaneko, Yasushi Ishihama, Norio Teshima, Yukihiro Esaka
RÉSUMÉ

Acetaldehyde (AA), which is present in tobacco smoke, automobile exhaust gases and alcohol beverage, is a mutagen and carcinogen. AA reacts with 2'-deoxyguanosine (dG) in DNA to form N

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Sigma-Aldrich
2′-Deoxycytidine, ≥99% (HPLC)