- miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.
miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.
Cell death & disease (2017-10-06)
Mei Zhang, Qun Zhang, Yali Hu, Lu Xu, Yue Jiang, Chunxue Zhang, Lijun Ding, Ruiwei Jiang, Jianxin Sun, Haixiang Sun, Guijun Yan
PMID28981116
RÉSUMÉ
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here, we found that miR-181a was upregulated in hydrogen peroxide (H
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