- NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels.
NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels.
Dalton transactions (Cambridge, England : 2003) (2014-07-01)
Serena Pillozzi, Luca Gasparoli, Matteo Stefanini, Mirco Ristori, Massimo D'Amico, Enzo Alessio, Federica Scaletti, Andrea Becchetti, Annarosa Arcangeli, Luigi Messori
PMID24975719
RÉSUMÉ
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.
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