Accéder au contenu
MilliporeSigma

Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids.

Scientific reports (2017-09-09)
Kristina Hofmann, Rosalia Rodriguez-Rodriguez, Anne Gaebler, Núria Casals, Anja Scheller, Lars Kuerschner
RÉSUMÉ

The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell types. While the major function of oligodendrocytes is the formation of the lipid-rich myelin structure, the heterogeneous group of astrocytes fulfils a multitude of important roles in cerebral development and homeostasis. Brain lipid homeostasis involves the synthesis of a specific cerebral lipidome by local lipid metabolism. In this study we have investigated the fatty acid uptake and lipid biosynthesis in grey and white matter regions of the murine brain. Key findings were: (i) white matter oligodendrocytes and astrocytes take up saturated and unsaturated fatty acids, (ii) different grey matter regions show varying lipid labelling intensities, (iii) the medial habenula, an epithalamic grey matter structure, and the oligodendrocytes and astrocytes therein are targeted by fatty acids, and (iv) in the medial habenula, the neutral lipid containing lipid droplets are found in cells facing the ventricle but undetectable in the habenular parenchyma. Our data indicate a role for oligodendrocytes and astrocytes in local lipid metabolism of white and grey matter regions in the brain.

MATÉRIAUX
Référence du produit
Marque
Description du produit

Sigma-Aldrich
Anticorps anti-Olig-2, Chemicon®, from rabbit
Référence
Conditionnement
Disponibilité
Prix
Quantité
Sigma-Aldrich
17-Octadecynoic acid, ≥95% (GC)
Référence
Conditionnement
Disponibilité
Prix
Quantité