- Experience-dependent regulation of NG2 progenitors in the developing barrel cortex.
Experience-dependent regulation of NG2 progenitors in the developing barrel cortex.
Nature neuroscience (2012-08-14)
Jean-Marie Mangin, Peijun Li, Joseph Scafidi, Vittorio Gallo
PMID22885848
RÉSUMÉ
We found that, during the formation of the mouse barrel cortex, NG2 cells received glutamatergic synapses from thalamocortical fibers and preferentially accumulated along septa separating the barrels. Sensory deprivation reduced thalamocortical inputs on NG2 cells and increased their proliferation, leading to a more uniform distribution in the deprived barrels. Thus, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development.