- 2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters (2001-02-24)
S S Shin, M S Noh, Y J Byun, J K Choi, J Y Kim, K M Lim, J Y Ha, J K Kim, C H Lee, S Chung
PMID11206450
RÉSUMÉ
A series of 2,2-dimethyl-5-[4-(methylsulfonyl)phenyl]-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).
MATÉRIAUX