- Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Bioorganic & medicinal chemistry letters (2004-12-18)
Gregory H Merriman, Liang Ma, Patrick Shum, Daniel McGarry, Frank Volz, Jeffrey S Sabol, Alexandre Gross, Zhicheng Zhao, David Rampe, Lin Wang, Friederike Wirtz-Brugger, Bruce A Harris, Douglas Macdonald
PMID15603968
RÉSUMÉ
A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.
MATÉRIAUX