- Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe.
Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe.
Chemical communications (Cambridge, England) (2011-06-02)
Krishna Kanta Ghosh, Hyung-Ho Ha, Nam-Young Kang, Yogeswari Chandran, Young-Tae Chang
PMID21629953
RÉSUMÉ
We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.
MATÉRIAUX