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General base-guanidinium cooperation in bifunctional artificial phosphodiesterases.

The Journal of organic chemistry (2011-05-27)
Riccardo Salvio, Roberta Cacciapaglia, Luigi Mandolini
RÉSUMÉ

Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 × 10(4) in the most favorable case.

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Description du produit

Sigma-Aldrich
m-Xylene, ReagentPlus®, 99%
Sigma-Aldrich
m-Xylene, anhydrous, ≥99%
Sigma-Aldrich
m-Xylene, puriss. p.a., ≥99.0% (GC)
Supelco
m-Xylene, analytical standard
Supelco
m-Xylene, Pharmaceutical Secondary Standard; Certified Reference Material