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Evaluation of binding properties of Plantago psyllium seed mucilage.

Acta pharmaceutica (Zagreb, Croatia) (2010-12-08)
Majid Saeedi, Katayoun Morteza-Semnani, Farshad Ansoroudi, Saeed Fallah, Gholamreza Amin
RÉSUMÉ

Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (m/m) was found to be comparable with 3 % (m/m) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.

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Sigma-Aldrich
Tragacanth