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RANTES: a versatile and controversial chemokine.

Trends in immunology (2001-04-05)
V Appay, S L Rowland-Jones
RÉSUMÉ

The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.