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A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis.

Lab on a chip (2019-09-27)
Gwang-Noh Ahn, Taejong Yu, Hyune-Jea Lee, Ki-Won Gyak, Ji-Ho Kang, Donghyun You, Dong-Pyo Kim
RÉSUMÉ

Microreactors are emerging as an efficient, sustainable synthetic tool compared to conventional batch reactors. Here, we present a new numbering-up metal microreactor by integrating a flow distributor and a copper catalytic module for high productivity of a commercial synthetic drug. A flow distributor and an embedded baffle disc were manufactured by CNC machining and 3D printing of stainless steel (S/S), respectively, whereas a catalytic reaction module was composed of 25 copper coiled capillaries configured in parallel. Eventually, the numbering-up microreactor system assembled with functional modules showed uniform flow distribution and high mixing efficiency regardless of clogging, and achieved high-throughput synthesis of the drug "rufinamide", an anticonvulsant medicine, via a Cu(i)-catalyzed azide-alkyne cycloaddition reaction under optimized conditions.

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Sigma-Aldrich
Methyl propiolate, 99%
Sigma-Aldrich
2,6-Difluorobenzyl bromide, 97%