SML1664

Deoxynivalenol Ready Made Solution

1 mg/mL

• Synonyme(s) : (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 4-Deoxynivalenol, DON, Dehydronivalenol, RD-toxon, Vomitoxin
• Formule empirique (notation de Hill): C₁₅H₂₀O₆
• Numéro CAS: 51481-10-8
• Poids moléculaire : 296.32
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Fusarium sp. (Fusarium asiaticum)
• Niveau de qualité: 200
• Forme: solution (ethanol: 2-propanol 95:5)
• Conditions de stockage: protect from light
• Concentration: 1 mg/mL
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
• Clé InChI: LINOMUASTDIRTM-QGRHZQQGSA-N

Description

Actions biochimiques/physiologiques

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.

Notes préparatoires

Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 57.2 °F
• Point d'éclair (°C): 14 °C