SML1013

PRT4165

≥98% (HPLC)

• Synonyme(s) : 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethylene)-1,3-indandione, NSC 600157
• Formule empirique (notation de Hill): C₁₅H₉NO₂
• Numéro CAS: 31083-55-3
• Poids moléculaire : 235.24
• Numéro MDL: MFCD00435709
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825631
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1C(C(C2=C1C=CC=C2)=O)=CC3=CN=CC=C3
• InChI: 1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
• Clé InChI: OMHZFEWYVFWVLI-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable