J4080

JTE-013

≥98% (HPLC)

• Synonyme(s) : 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide
• Formule empirique (notation de Hill): C₁₇H₁₉N₇OCl₂
• Numéro CAS: 383150-41-2
• Poids moléculaire : 408.29
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: DMSO: ≥20 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
• Clé InChI: RNSLRQNDXRSASX-UHFFFAOYSA-N

Description

Application

JTE-013 has been used in in vitro blood−brain barrier (BBB) and blood−tumor barrier (BTB) assays.

Actions biochimiques/physiologiques

JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

JTE-013 is a selective sphingosine 1-phosphate (S1P) receptor antagonist. JTE-013 is highly selective for S1P2 (EDG-5). It inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 mM, JTE-013 displays 4.2% inhibition of S1P3 and does not antagonise S1P1.

Caractéristiques et avantages

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable