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I2406

Sigma-Aldrich

Interleukin-11 human

>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Synonyme(s) :

IL-11

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About This Item

Numéro MDL:
MFCD00212208
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in baculovirus infected Sf21 cells

Pureté

>97% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.06-0.24 ng/mL ED50

Poids mol.

23 kDa

Conditionnement

pkg of 5 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P20809

Température de stockage

−20°C

Informations sur le gène

human ... IL11(3589)

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Catégories apparentées

Description générale

Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes.
The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein.

Actions biochimiques/physiologiques

Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.

Forme physique

Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.

Remarque sur l'analyse

The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

V F Quesniaux et al.
Blood, 80(5), 1218-1223 (1992-09-01)
Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for
I Kawashima et al.
FEBS letters, 283(2), 199-202 (1991-06-03)
A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open
W Klein et al.
Genes and immunity, 3(8), 494-496 (2002-12-18)
Inflammatory bowel diseases (IBD) are multifactorial disorders characterised by the host's inability to limit the inflammatory response to luminal antigens. The association of polymorphisms in the CARD15 gene with Crohn's disease (CD) demonstrates the relevance of activated transcription factor NF(kappa)B
I Kawashima et al.
Progress in growth factor research, 4(3), 191-206 (1992-01-01)
Interleukin-11 (IL-11) is a novel stroma-derived cytokine that acts on both hematopoietic progenitors and stromal cells. IL-11 was originally identified in a medium conditioned by the macaque bone marrow-derived stromal cell line PU-34 and cloned as a growth factor for
Interleukin-11: a cytokine signaling through gp130 with pleiotropic effects and potential clinical utility within and outside the hematopoietic system.
Jacobsen, S.E.W. et al.
The Cytokine Handbook, 365-365 (1998)
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