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GW20079F

Sigma-Aldrich

Anti-Vitamin D-Binding Protein antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-VDBP

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

indirect ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

NP_000574.2

Numéro d'accès UniProt

P02774

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GC(2638)

Immunogène

Immunogen Sequence: GI # 32483410, sequence 1-474
Vitamin D-binding protein (native protein).

Application

Anti-Vitamin D-Binding Protein antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Vitamin D-binding protein (also known as gc-globulin) is a protein encoded by the GC gene in humans. It transports vitamin D metabolites in the circulation. Both vitamin D metabolites and vitamin D binding proteins (VDBP) are associated with asthma (regulation in the lung during acute allergen-induced airway inflammation). Vitamin D-binding protein (VDBP) haplotypes also influence free vitamin D levels.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Aledie Navas-Nazario et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(6), 519-524 (2014-04-22)
Potential vitamin D-related influences on inflammatory diseases such as asthma are controversial, including the suggestion that vitamin D insufficiency is associated with increased asthma morbidity. Vitamin D-binding protein transports vitamin D metabolites in the circulation. Single nucleotide polymorphisms in the
A G Randolph et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(2), 231-237 (2014-01-23)
Between 75 000 and 125 000 U.S. infants are hospitalized for respiratory syncytial virus (RSV) bronchiolitis every year. Up to half will be diagnosed with asthma in later childhood. Vitamin D deficiency has been associated with susceptibility to asthma and respiratory infections.
K Bratke et al.
Clinical and experimental immunology, 177(1), 366-372 (2014-04-16)
Allergic asthma is a chronic disease of the airways associated with airway hyperresponsiveness, a variable degree of airflow obstruction, airway remodelling and a characteristic airway inflammation. Factors of the vitamin D axis, which include vitamin D metabolites and vitamin D

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