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B7652

Sigma-Aldrich

Betamethasone 21-phosphate disodium

≥97%

Synonyme(s) :

Betamethasone disodium phosphate, Betamethasone sodium phosphate

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About This Item

Formule empirique (notation de Hill):
C22H28FNa2O8P
Numéro CAS:
151-73-5
Poids moléculaire :
516.40
Numéro CE :
205-797-0
Numéro MDL:
MFCD00200361
Code UNSPSC :
12352200
ID de substance PubChem :
24892013
Nomenclature NACRES :
NA.77

Stérilité

non-sterile

Pureté

≥97%

Forme

powder

Solubilité

water: 50 mg/mL, clear to very slightly hazy, faintly yellow

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

Clé InChI

PLCQGRYPOISRTQ-LWCNAHDDSA-L

Informations sur le gène

human ... NR3C1(2908)

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Actions biochimiques/physiologiques

Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.

Implications diagnostiques

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H360FD,H373

Classification des risques

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

Organes cibles

Liver,Kidney,Endocrine system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial
Dalziel SR, et al.
Lancet, 365(9474), 1856-1862 (2005)
Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet/Dovobet/Taclonex) in the treatment of psoriasis vulgaris
Kragballe K, et al.
Dermatology (Basel, Switzerland), 213(4), 319-326 (2006)
Tsutomu Sakai et al.
Investigative ophthalmology & visual science, 52(3), 1516-1521 (2010-12-24)
The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. EAU was induced by
Masatomo Kato et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 27(4), 353-360 (2011-05-18)
Glucocorticoids exert their actions via the glucocorticoid receptor through at least 2 intracellular mechanisms, known as transrepression and transactivation. It has been hypothesized that transrepression is the basis of their anti-inflammatory effects, whereas transactivation has been assumed to cause their
Alan H Jobe et al.
American journal of obstetrics and gynecology, 201(6), 611-611 (2009-10-06)
We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically. Ewes with singleton pregnancies were treated with single doses of 0.25-mg/kg or 0.5-mg/kg betamethasone acetate, 4 doses of 0.25-mg/kg betamethasone
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