16866

Monoethylglycinexylidine

analytical standard

• Synonyme(s) : MEGX, MGEX, Monoethylglycinexylidide, N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide, Norlidocaine
• Formule empirique (notation de Hill): C₁₂H₁₈N₂O
• Numéro CAS: 7728-40-7
• Poids moléculaire : 206.28
• Numéro MDL: MFCD00098991
• Code UNSPSC : 41116107
• ID de substance PubChem : 329751403
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 100
• Pureté: ≥98.0% (HPLC)
• Durée de conservation: limited shelf life, expiry date on the label
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Application(s): pharmaceutical
• Format: neat
• Chaîne SMILES: CC1=C(NC(CNCC)=O)C(C)=CC=C1
• InChI: 1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
• Clé InChI: WRMRXPASUROZGT-UHFFFAOYSA-N

Description

Application

• Pharmacokinetic Analysis: A study by Liu ZY et al. examines the pharmacokinetics of intravenous and topical lidocaine in patients undergoing thoracoscopic pulmonary resection. This research, which could integrate compounds like Monoethylglycinexylidine for analytical validation, highlights the importance of understanding drug dynamics for improving surgical outcomes (Liu et al., 2024).


• Veterinary Pharmacology: Knych HK et al. explore the pharmacokinetics and metabolism of lidocaine in horses following a palmar digital nerve block. Studies like this could benefit from the use of Monoethylglycinexylidine as a standard for accurate drug measurement and monitoring in veterinary medicine, ensuring safe and effective dosing (Knych et al., 2023).


• Anesthesia Research: Crouch CE et al. provide insights into the pharmacokinetics of lidocaine intraoperative infusion during partial hepatectomy for living liver donation. Research utilizing Monoethylglycinexylidine could enhance the understanding of local anesthetics′ systemic effects, contributing to safer anesthetic practices (Crouch et al., 2023).


• Anesthetic Efficacy in Avian Species: Escobar A et al. investigate the effects of two continuous infusion doses of lidocaine on isoflurane minimum anesthetic concentration in chickens. Incorporating Monoethylglycinexylidine in such studies could refine our understanding of dose-dependent effects and optimize anesthetic protocols for non-mammalian species (Escobar et al., 2023).


• Clinical Pharmacokinetics: Jin Y et al. discuss the simultaneous determination of lidocaine and its active metabolites in plasma by UPLC-MS/MS, applied to a clinical pharmacokinetic study in liver cancer patients. Monoethylglycinexylidine could be used to validate and calibrate assays, enhancing the reliability of pharmacokinetic data in clinical settings (Jin et al., 2022).

Actions biochimiques/physiologiques

Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P310
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable