MABF389

Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

clone UC10-4F10-11, 0.2 mg/mL, from hamster(Armenian)

• Synonyme(s) : Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: hamster (Armenian)
• Niveau de qualité: 100
• Conjugué: Allophycocyanin conjugate
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: UC10-4F10-11, monoclonal
• Espèces réactives: mouse
• Concentration: 0.2 mg/mL
• Technique(s): flow cytometry: suitable
• Isotype: IgG
• Numéro d'accès UniProt: P09793
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... Ctla4(12477)

Description

Description générale

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Immunogène

Immunogen information for this antibody is proprietary information.

Application

Research Category
Inflammation & Immunology

This armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), APC & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).

Qualité

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 μg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

Forme physique

Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

Size Exclusion Chromatography

Stockage et stabilité

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable