528105

Picrotoxin, Anamirta cocculin

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

• Synonyme(s) : Picrotoxin, Anamirta cocculin
• Formule empirique (notation de Hill): C₁₅H₁₈O₇ · C₁₅H₁₆O₆
• Numéro CAS: 124-87-8
• Poids moléculaire : 602.58
• Numéro MDL: MFCD00074824
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (mixture of Picrotoxin and picrotin, HPLC)
• Forme: crystals; powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white to light yellow
• Solubilité: aqueous base: 3 mg/mL; ethanol: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• InChI: 1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1
• Clé InChI: VJKUPQSHOVKBCO-ZTYBEOBUSA-N

Description

Description générale

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^- channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
GABA receptors

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

Avertissement

Toxicity: Highly Toxic (H)

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable