444286-M

MMP-2 Inhibitor II

The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP-2 Inhibitor II, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
• Formule empirique (notation de Hill): C₁₆H₁₇NO₆S₂
• Numéro CAS: 869577-51-5
• Poids moléculaire : 383.44
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Puissance: 2.4 μM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Couleur: white
• Solubilité: DMSO: 200 mg/mL
• Température de stockage: −20°C
• InChI: 1S/C16H17NO6S2/c1-24(18,19)17-12-2-4-13(5-3-12)23-14-6-8-16(9-7-14)25(20,21)11-15-10-22-15/h2-9,15,17H,10-11H2,1H3
• Clé InChI: ADEXXMLIERNFQB-UHFFFAOYSA-N

Description

Description générale

An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (K_i = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (K_i = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.

Actions biochimiques/physiologiques

Secondary Target
MMP-2 (K_i = 45 and 379 µM for MMP-1 and MMP-7, respectively)

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable