14-522-M

ABL (T315I) Protein, active

recombinant, expressed in baculovirus infected Sf21 cells

• Code UNSPSC : 12352200
• eCl@ss : 32160405
• Nomenclature NACRES : NA.41

Propriétés

• product name: Abl (T315I) Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation. For use in Kinase Assays.
• Source biologique: human
• Produit recombinant: expressed in baculovirus infected Sf21 cells
• Poids mol.: M_w 121 kDa
• Fabricant/nom de marque: Upstate^®
• Technique(s): activity assay: suitable (kinase)
• Numéro d'accès NCBI: NM_005157.3; NM_007313.2
• Numéro d'accès UniProt: P00519

Description

Description générale

N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation

Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.

Product Source: Expressed by baculovirus in Sf21 insect cells

Application

Research Category
Metabolism

Inflammation & Immunology

Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

Actions biochimiques/physiologiques

Protein Target: Abl

Target Sub-Family: TK

Conditionnement

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.

Qualité

routinely evaluated by phosphorylation of Abltide

Forme physique

Ni²⁺/NTA-agarose

Stockage et stabilité

6 months at -70°C

Autres remarques

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.